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QUESTION: I am Type A and am two weeks on the diet. My mother-in-law (O) and sister-in-law (A) also are on this and we are all doing very well. However we are all confused about the use of "domestic mushrooms." What is a domestic mushroom? Is it a common white "button cap" mushroom?
ANSWER: Yes, 'domestic' or 'common' mushroom is also called 'button cap.' The species is Agaricus bisporus.
Recent research seems to indicate that Agaricus bisporus has a lectin with the potential to induce early mutations in the colon to revert back to normal. As such it may be a very important addition to the diet is you have a family history of colon cancer or have been diagnosed with colon polyps, an early warning sign.
1. Yu LG, Fernig DG, White MR, Spiller DG, Appleton P, Evans RC, Grierson I, Smith JA, Davies H, Gerasimenko OV, Petersen OH, Milton JD, Rhodes JM. Edible mushroom (Agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import. J Biol Chem. 1999 Feb 19;274(8):4890-9.
2.Yu LG, Fernig DG, Rhodes JM. Intracellular trafficking and release of intact edible mushroom lectin from HT29 human colon cancer cells. Eur J Biochem. 2000 Apr;267(7):2122-6.
3. Yu L, Fernig DG, Smith JA, Milton JD, Rhodes JM. Reversible inhibition of proliferation of epithelial cell lines by Agaricus bisporus (edible mushroom) lectin. Cancer Res. 1993 Oct 1;53(19):4627-32.