STUDY: Heart possesses a population of cardiac stem cells

JOURNAL: The New England Journal of Medicine 2002;346:5-15, 55-56

AUTHORS: Dr. Piero Anversa

ABSTRACT: In a study that turns on its head the traditional view that the heart cannot help heal itself, scientists have found evidence that the organ may indeed harbor stem-cell reserves capable of regenerating damaged tissue.

COMMENTARY: The study of men who received heart transplants from female donors revealed that primitive cells from the recipients migrated into the donor hearts, after which new muscle cells and small blood vessels formed. The researchers were able to pin down the phenomenon by finding a considerable number of cells in the donor heart that bore the Y chromosome--the "male" sex chromosome, which could only have come from the transplant recipients themselves.

Dr. Piero Anversa of New York Medical College in Valhalla said his team believes primitive cells moved to the donor hearts from the remaining portions of the transplant recipients' own hearts, although the study does not prove this. Anversa explained that his team could not rule out the possibility that the cells traveled to the heart from the bone marrow, which contains the stem cells that give rise to blood.

The study indicates that the heart possesses a population of cardiac stem cells...implying that the heart has the capacity to regenerate itself.

And that idea is at odds with the cardiology "dogma" that there is no such thing as cardiac stem cells--populations of immature cells within the heart that have the potential to divide, proliferate and replace mature cells killed off by heart attack and disease.

Now that there is strong evidence of the heart's regenerative capacity, scientists can study the possibility of harnessing this self-healing potential to treat damaged heart.

The study looked at autopsied tissue from eight men who died sometime after receiving a heart from a female donor. The patients had lived with their new hearts for anywhere from 4 to 552 days.

Anversa's team found that up to 20% of the cells in the men's heart muscle and small blood vessels called arterioles and capillaries bore the Y chromosome. Even the patient who died 4 days after his transplant had Y-bearing cells in the donor heart.

According to the researchers, this suggests that the recipients' own primitive cells moved into the foreign heart and matured to aid in the "remodeling" of the organ. In addition, when they looked at a small group of autopsied normal hearts, the investigators found small populations of immature cells. And if heart stem cells can indeed form new heart tissue, it is still unclear what "mobilizes" them into action. His team is currently using animal models to study what signaling mechanisms--such as growth factors--are needed.

If researchers can figure out how to mobilize self-repair cells in the heart, they could become an important weapon against a "host of disorders" including coronary artery disease and heart muscle conditions.

The therapeutic implications would be enormous since at least 600,000 Americans develop heart failure every year and many of them die within 2 to 3 years.

STUDY: Despite dangers,infants placed in front seats

JOURNAL: National Highway Transportation Safety Administration

AUTHORS: Dr. Jeffrey Runge

ABSTRACT: Seat belt use for children is at a record high, but too many infants and young children still are being placed at risk by riding in front seats.

COMMENTARY: A survey by the National Highway Transportation Safety Administration found 15 percent of infants were riding in the front seat, where they are at increased risk of injury from crashes or deploying air bags even if they are in infant seats.

The survey found 10 percent of 1- to 3-year-olds and 29 percent of 4- to 7-year-olds also were riding in the front seat. NHTSA and the American Academy of Pediatrics recommends that children 12 and under ride in the back seat.

“There are new parents every day, and even those old parents who need to be reminded: The only way to keep these children safe is to put them in a child safety seat appropriate to their age in the back seat,” said Dr. Jeffrey Runge, NHTSA’s chief.