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Effect of curcumin on bone marrow
STUDY: Eat your Tumeric
JOURNAL: ENVIRONMENTAL MUTAGENESIS, 2000, Vol 465, Iss 1-2, pp 131-137
AUTHORS:
ABSTRACT: Dietary antioxidants are showing evidence of preventing chromosomal damage in non-tumor cells, which is induced by anti-tumor drugs.
COMMENTARY: Curcumin is a dietary antioxidant that has been reported to protect against disruption or breakages in chromosomes.
A study investigated the effects of curcumin on chromosomal aberrations in rat bone marrow cells and whether there is any enhancement of these effects with the combination of curcumin and vitamin C. Animals treated with curcumin plus a single dose of cisplatin (an anti-tumor drug), between 18-72 hours after the drug.
The results showed a significant reduction in the total amount of chromosomal damage and in the number of abnormal metaphases (2nd stage of cell division). Thus, curcumin could prevent damage to chromosomes, caused by a tumor suppressor drug, by acting as a free radical scavenger.
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