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Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.
STUDY: Licorice for SARS
JOURNAL: Lancet (2003Jun14)
AUTHORS: Cinatl J ,Morgenstern B ,Bauer G ,Chandra P ,Rabenau H ,Doerr HW
ABSTRACT: The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection.
COMMENTARY: We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany.
Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS.